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Refinex ® botulinum toxin type A. Refinex Botox alternatives.




Refinex Botulinum toxin

Refinex Refinex is one best options for those who use Botox alternatives. Developed with a snake venom ingredient, REFinex is an effective anti-wrinkle treatment that works thanks to a synthetic effect derived from venom temple Viper. Refinex is produced in the process of breeding and keeping unique snakes to capture peptides of poisons for use in cosmetics. Other ingredients in an alternative Botox product include Hexapeptide, which is used to reduce muscle contraction. Marine algae biopeptides are used in Formula mainly to improve skin nutrition.

Refinex Botulinum Toxin type A for therapy, Refinex®botulinum toxin type A is a sterile and lyophilized highly purified protein obtained from ground toxin hall culture Clostridium botulinum strain . It is produced at GMP (Good manufacturing practice) pharmaceutical factory. A simple treatment with a botulinum toxin type drug, Refinex ®, can radically eliminate facial wrinkles and wrinkles on face. It is also indicated for the treatment belpharospasm, hemifacial spasm in adults, and certain types strabismus, hyperhidrosis, etc. More effective injections are extremely small doses botulinum toxin type a Refinex®, which can significantly relax certain facial muscles, thereby stopping their contraction and not allowing you to get rid of wrinkles and wrinkles.

Medical Research Institute, Japan

Botulinum toxin


"Cosmetics

Richard Clark, a plastic surgeon from Sacramento (CA), was first to document a cosmetic use for botulinum toxin.  He treated forehead asymmetry caused by left sided forehead nerve paralysis that occurred during a cosmetic facelift. Since injured nerve could possibly regenerate by 24 months, a two-year waiting period was necessary before definitive surgical treatment could be done. Clark realized that botulinum toxin, which had been previously used only for cross eyed babies and facial tics, could also be injected to smooth wrinkles right forehead to match her paralyzed left. He received FDA approval for this cosmetic application toxin and successfully treated person and published case study in 1989.

Marrying ophthalmology to dermatology, Jean and Alistair Carruthers observed that blepharospasm patients who received injections around the eyes and upper face also enjoyed diminished facial glabellar lines (“frown lines” between eyebrows), thereby initiating highly-popular cosmetic use toxin. Brin, and a group at Columbia University under Monte Keen made similar reports. In 2002, following clinical trials, FDA approved Botox Cosmetic, botulinum A toxin to temporarily improve the appearance of moderate-to-severe glabellar lines. FDA approved a fully in vitro assay for use in stability and potency testing Botox in response to increasing public concern that LD50 testing was required for each batch sold in market.

 

Cosmetic

The cosmetic effect BTX-A on wrinkles was originally documented by a plastic surgeon from Sacramento, California, Richard Clark, and published in journal Plastic and Reconstructive Surgery in 1989. Canadian husband and wife ophthalmologist and dermatologist physicians, JD and JA Carruthers, were first to publish a study on BTX-A for treatment glabellar frown lines in 1992. Similar effects had reportedly been observed by a number of independent groups (Brin, and the Columbia University group under Monte Keen. After formal trials, on April 12, 2002, FDA announced regulatory approval botulinum toxin type A (Botox Cosmetic) to temporarily improve appearance moderate-to-severe frown lines between the eyebrows (glabellar lines). Subsequently, cosmetic use botulinum toxin type A has become widespread.[83] results otox Cosmetic can last up to four months and may vary with each patient. US Food and Drug Administration approved an alternative product-safety testing method in response to increasing public concern that LD50 testing was required for each batch sold in market."


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